Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 AlteredExpression LHGDN Expression of TNF-alpha, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis. 16820934

2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 AlteredExpression LHGDN Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. 18668547

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 AlteredExpression LHGDN JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-alpha. 16936264

2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 AlteredExpression LHGDN Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression. 16564576

2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 AlteredExpression LHGDN Anti-TNF therapy for rheumatoid arthritis and other inflammatory diseases. 11725485

2001
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 AlteredExpression LHGDN Regulation of TNF-alpha-mediated hyperplasia through TNF receptors, TRAFs, and NF-kappaB in synoviocytes obtained from patients with rheumatoid arthritis. 12067756

2002
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 AlteredExpression LHGDN Increased nuclear factor-kappaB activation in peripheral blood monocytes of patients with rheumatoid arthritis is mediated primarily by tumor necrosis factor-alpha. 17896809

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 AlteredExpression LHGDN Serum levels of glycated albumin, hsCRP, TNF-alpha and blood glycosylated hemoglobin A1c (HbA1c) were measured in 317 consecutive patients with T2DM and 309 normal controls. 17499233

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure 		0.600 AlteredExpression LHGDN [The effects of exercise training on plasma tumor necrosis factor-alpha, blood leucocyte and its components in congestive heart failure patients]. 12133434

2002
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure 		0.600 AlteredExpression LHGDN Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure. 18068948

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0021368
Disease: Inflammation
Inflammation 		0.600 AlteredExpression LHGDN Proinflammatory cytokines seem to be only partly involved in the pathophysiology of CRPS1, as indicated by the lack of coherence between TNF-alpha and IL-6 levels and the signs and symptoms of inflammation and disease duration. 18055234

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0021368
Disease: Inflammation
Inflammation 		0.600 AlteredExpression LHGDN Tumor necrosis factor-alpha is associated with increased protein C activation in nonobese type 2 diabetic patients. 14988320

2004
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 AlteredExpression LHGDN Increased TNF-alpha and decreased TGF-beta expression in peripheral blood leukocytes after acute myocardial infarction. 16718633

2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 AlteredExpression LHGDN Elevated TNF-alpha levels are associated with increased MI risk. 16243340

2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.600 AlteredExpression LHGDN The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke. 14681891

2003
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.600 AlteredExpression LHGDN Tumor necrosis factor-alpha induces apoptosis of enterocytes in mice with fulminant hepatic failure. 15968724

2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 AlteredExpression LHGDN Intratesticular delivery of tumor necrosis factor-alpha and ceramide directly abrogates steroidogenic acute regulatory protein expression and Leydig cell steroidogenesis in adult rats. 12959973

2003
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 AlteredExpression LHGDN [The postburn changes of the plasma levels of PGE2 and TNF alpha in burn patients]. 11774822

2001
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.400 AlteredExpression LHGDN NF-kappaB-dependent MnSOD expression protects adenocarcinoma cells from TNF-alpha-induced apoptosis. 12032830

2002
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.400 AlteredExpression LHGDN Relative expression levels of Th1 and Th2 cytokine mRNA are independent prognostic factors in patients with ovarian cancer. 15870936

2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0002871
Disease: Anemia
Anemia 		0.400 AlteredExpression LHGDN Our study found that the anemia of chronic kidney disease was associated with up regulation of TNF-alpha, and possibly IL-6 and IL-8 along with increased levels of these proinflammatory cytokines in patients treated with epoetin. 18547996

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.400 AlteredExpression LHGDN Enhanced TNF-alpha production may also promote atherosclerosis due to increased insulin resistance and the expression of adhesion molecules. 14630568

2004
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.400 AlteredExpression LHGDN HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR. 17531241

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 AlteredExpression LHGDN Colonic myofibroblasts were isolated from patients with active CD and controls. mTNF was evaluated by Western blotting and flow cytometry. 17631138

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.400 AlteredExpression LHGDN This finding might suggest a pathogenic role of the TNF-alpha system in the development of cardiovascular disease in T1DM. 16260427

2005